Cell Biology of the Ovary

Part I. Development of ovary; 1. Reconstitution of human germ cell development in vitro.- 2. Regulation of steroidogenesis in gonads by Ad4BP/SF-1.- 3. Role of Hedgehog-BMP4 signaling in gonadogenesis.- Part II. Ovarian stem cells and cancer stem cells; 4. Role of Lgr5-expressing stem cells in epithelial renewal and cancer in reproductive tract.- 5. Characteristics of ovarian cancer stem cells.- 6. Role of CD44 variant 6 in ovarian cancer stem cells.- Part III. Strategies for fertility preservation; 7. Rescue from primary ovarian insufficiency.- 8. Ovarian tissue cryopreservation and transplantation.- 9. Clinical management of primary ovarian insufficiency.- Part IV. Molecular and clinical aspects of epithelial ovarian cancer; 10. Molecular pathogenesis of epithelial ovarian cancer.- 11. Clinical management of epithelial ovarian cancer.- 12. Molecular targeted therapy for epithelial ovarian cancer.

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• Medicina reproductiva
• Ginecologia e Obstetricia
• Oncologia

Ovarian tissue;Ovarian cancer;Stem cell;Ovarian surface epithelial cells;Primordial germ cells