System Engineering Approach to Planning Anticancer Therapies

System Engineering Approach to Planning Anticancer Therapies

Psiuk-Maksymowicz, Krzysztof; Kimmel, Marek; Puszynski, Krzysztof; Swierniak, Andrzej; Smieja, Jaroslaw

Springer International Publishing AG

05/2016

235

Dura

Inglês

9783319280936

15 a 20 dias

633

Descrição não disponível.
Introduction.- Cell Cycle as an Object of Control.- Therapy Optimization in Population Dynamics Models.- Structured Models and Their Use in Modeling Anticancer Therapies.- Signaling Pathways Dynamics and Cancer Treatment.- Model Identification and Parameter Estimation.- Appendixes: Stability and Controllability of Dynamical Systems.- Pontryagin Maximum Principle and Optimal Control.- Bifurcation Analysis.- Numerical Implementation of the Runge Kutta and Gillespie Methods.
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biomathematical modelling;anticancer therapies;structure models;signalling pathway dynamics;population dynamics;optimimzation;cell cycle;drug resistance;93A30; 92C42, 49N90, 92D25, 37N25, 92C50, 93C95, 35Q92, 93B35.;Cell Cycle Analysis;antibacterial drug resistance