Retinal Degenerative Diseases
Retinal Degenerative Diseases
Mechanisms and Experimental Therapy
LaVail, Matthew M.; Hollyfield, Joe; Ash, John; Bowes Rickman, Catherine; Grimm, Christian; Anderson, Robert E.
Springer International Publishing AG
08/2016
824
Mole
Inglês
9783319371528
15 a 20 dias
Retinal Dystrophy.- Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy.- The Development of a Cat Model of Retinal Detachment and Re-Attachment.- Part V Mechanisms of Degeneration.- The Role of X-Chromosome Inactivation in Retinal Development and Disease.- A Non-canonical Role for ?-Secretase in the Retina.- The Consequences of Hypomorphic RPE65 for Rod and Cone Photoreceptors.- The Rate of Vitamin A Dimerization in Lipofuscinogenesis, Fundus Autofluorescence, Retinal Senescence and Degeneration.- Can Vitamin A be Improved to Prevent Blindness due to Age-Related Macular Degeneration, Stargardt Disease and Other Retinal Dystrophies?.- Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina.- Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic Targets.- Neuronal Nitric Oxide Synthase as a Trigger of the N-methyl-N-nitrosourea-induced Photoreceptor Cell Death.- Molecular Principles for Decoding Homeostasis Disruptions in the Retinal Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseases.- Aging and Vision.- Part VI Neuroprotection, Small Molecules & Related Therapeutic Approaches.- The Potential Use of PGC-1? and PGC-1? to Protect the Retina by Stimulating Mitochondrial Repair.- Retinal Caveolin-1 Modulates Neuroprotective Signaling.- Photoreceptor Neuroprotection: Regulation of Akt activation through Serine/Threonine Phosphatases, PHLPP and PHLPPL.- The Role of AMPK pathway in Neuroprotection.- Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1.- Near-Infrared Photobiomodulation in Retinal Injury and Disease.- Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns.- Small Molecules that Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models.- Histone Deacetylase: Therapeutic Targets in Retinal Degeneration.- Therapeutic Approach of Nanotechnology for Oxidative Stress Induced Ocular Neurodegenerative Diseases.- Transscleral Controlled Delivery of Geranylgeranylaceton Using a Polymeric Device Protects Rat Retina Against Light Injury.- Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa.- Part VII Gene Therapy & Antisense.- Gene Therapy for MERTK-Associated Retinal Degenerations.- Tamoxifen-containing Eye Drops Successfully Trigger Cre-mediated Recombination in the Entire Eye.- Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages.- Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin.- Antisense Oligonucleotide Therapy for Inherited Retinal Dystrophies.- Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins.- Evaluation of Ocular Gene Therapy in an Italian Patient Affected by Congenital Leber Amaurosis Type 2 Treated in Both Eyes.-Part VIII Stem Cells & Cell-based Therapies.- Regenerative Medicine: Solution in Sight.- Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-derived Retinal Pigment Epithelium Cells.- Human Retinal Pigment Epithelium Stem Cell (RPESC).- Embryonic Stem Cell-Derived Microvesicles: Could They Be Used for Retinal Regeneration?.- Intravitreal Implantation of Genetically Modified Autologous Bone Marrow-Derived Stem Cells for Treating Retinal Disorders.- Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina.- Interkinetic Nuclear Migration in the Regenerating Retina.- Part IX Photoreceptors & Inner Retina.- Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.- A Novel Approach to Identify Photoreceptor Compartment-Specific Tulp1 Binding Partners.- Thyroid Hormone Signaling and Cone Photoreceptor Viability.- In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.- The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium.- Regulation of Retinal Development Via the Epigenetic Modification of Histone.- The Potential Role of Flavins and Retbindin in Retinal Function and Homeostasis.- Identification of Tyrosine O Sulfated Proteins in Cow Retina and the 661W Cell Line.- The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.-Characterization of Antibodies to Identify Cellular Expression of Dopamine.- Receptor 4.- A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina.- JNK Inhibition Reduced Retinal Ganglion Cell Death After Ischemia/Reperfusion In Vivo and After Hypoxia In Vitro.- Cell Fate of Mueller Cells During Photoreceptor Regeneration in an MNU-induced Retinal Degeneration Model of Zebrafish.- Polymodal Sensory Integration in Retinal Ganglion Cells.- Pigment Epithelium-derived Factor, a Protective Factor for Photoreceptors In Vivo.- Part X Retinal Pigment Epithelium (RPE).- The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells.- Live Imaging of LysoTracker-Labelled Phagolysosomes Tracks Diurnal Phagocytosis of Photoreceptor Outer Segment Fragments in Rat RPE Tissue Ex Vivo.- Cre Recombinase: You Can't Live with It, and You Can't Live without It.- Efficiency of Membrane Protein Expression Following Infection with Recombinant Adenovirus of Polarized Non-Transformed Human Retinal Pigment Epithelial Cells.- Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: maxiK, Cav1.3 and Bestrophin-1.- Lysosomal Trafficking Regulator (LYST).- Live-cell Imaging of Phagosome Motility in Primary Mouse RPE Cells.- RPE Cell and Sheet Properties in Normal and Diseased Eyes.- Valproic Acid Induced Human Retinal Pigment Epithelial Cell Death as Well as its Survival After Hydrogen Peroxide Damage is Mediated by P38 Kinase.- Blockade of MerTK Activation by AMPK Inhibits RPE Cell Phagocytosis.- Modulation of V-ATPase by ?A3/A1-crystallin in the Retinal Pigment Epithelial Cells.- Proteomic Profiling of Cigarette Smoke Induced Changes in Retinal Pigment Epithelium Cells.- Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress.
Retinal Dystrophy.- Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy.- The Development of a Cat Model of Retinal Detachment and Re-Attachment.- Part V Mechanisms of Degeneration.- The Role of X-Chromosome Inactivation in Retinal Development and Disease.- A Non-canonical Role for ?-Secretase in the Retina.- The Consequences of Hypomorphic RPE65 for Rod and Cone Photoreceptors.- The Rate of Vitamin A Dimerization in Lipofuscinogenesis, Fundus Autofluorescence, Retinal Senescence and Degeneration.- Can Vitamin A be Improved to Prevent Blindness due to Age-Related Macular Degeneration, Stargardt Disease and Other Retinal Dystrophies?.- Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina.- Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic Targets.- Neuronal Nitric Oxide Synthase as a Trigger of the N-methyl-N-nitrosourea-induced Photoreceptor Cell Death.- Molecular Principles for Decoding Homeostasis Disruptions in the Retinal Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseases.- Aging and Vision.- Part VI Neuroprotection, Small Molecules & Related Therapeutic Approaches.- The Potential Use of PGC-1? and PGC-1? to Protect the Retina by Stimulating Mitochondrial Repair.- Retinal Caveolin-1 Modulates Neuroprotective Signaling.- Photoreceptor Neuroprotection: Regulation of Akt activation through Serine/Threonine Phosphatases, PHLPP and PHLPPL.- The Role of AMPK pathway in Neuroprotection.- Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1.- Near-Infrared Photobiomodulation in Retinal Injury and Disease.- Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns.- Small Molecules that Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models.- Histone Deacetylase: Therapeutic Targets in Retinal Degeneration.- Therapeutic Approach of Nanotechnology for Oxidative Stress Induced Ocular Neurodegenerative Diseases.- Transscleral Controlled Delivery of Geranylgeranylaceton Using a Polymeric Device Protects Rat Retina Against Light Injury.- Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa.- Part VII Gene Therapy & Antisense.- Gene Therapy for MERTK-Associated Retinal Degenerations.- Tamoxifen-containing Eye Drops Successfully Trigger Cre-mediated Recombination in the Entire Eye.- Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages.- Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin.- Antisense Oligonucleotide Therapy for Inherited Retinal Dystrophies.- Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins.- Evaluation of Ocular Gene Therapy in an Italian Patient Affected by Congenital Leber Amaurosis Type 2 Treated in Both Eyes.-Part VIII Stem Cells & Cell-based Therapies.- Regenerative Medicine: Solution in Sight.- Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-derived Retinal Pigment Epithelium Cells.- Human Retinal Pigment Epithelium Stem Cell (RPESC).- Embryonic Stem Cell-Derived Microvesicles: Could They Be Used for Retinal Regeneration?.- Intravitreal Implantation of Genetically Modified Autologous Bone Marrow-Derived Stem Cells for Treating Retinal Disorders.- Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina.- Interkinetic Nuclear Migration in the Regenerating Retina.- Part IX Photoreceptors & Inner Retina.- Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.- A Novel Approach to Identify Photoreceptor Compartment-Specific Tulp1 Binding Partners.- Thyroid Hormone Signaling and Cone Photoreceptor Viability.- In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.- The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium.- Regulation of Retinal Development Via the Epigenetic Modification of Histone.- The Potential Role of Flavins and Retbindin in Retinal Function and Homeostasis.- Identification of Tyrosine O Sulfated Proteins in Cow Retina and the 661W Cell Line.- The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.-Characterization of Antibodies to Identify Cellular Expression of Dopamine.- Receptor 4.- A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina.- JNK Inhibition Reduced Retinal Ganglion Cell Death After Ischemia/Reperfusion In Vivo and After Hypoxia In Vitro.- Cell Fate of Mueller Cells During Photoreceptor Regeneration in an MNU-induced Retinal Degeneration Model of Zebrafish.- Polymodal Sensory Integration in Retinal Ganglion Cells.- Pigment Epithelium-derived Factor, a Protective Factor for Photoreceptors In Vivo.- Part X Retinal Pigment Epithelium (RPE).- The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells.- Live Imaging of LysoTracker-Labelled Phagolysosomes Tracks Diurnal Phagocytosis of Photoreceptor Outer Segment Fragments in Rat RPE Tissue Ex Vivo.- Cre Recombinase: You Can't Live with It, and You Can't Live without It.- Efficiency of Membrane Protein Expression Following Infection with Recombinant Adenovirus of Polarized Non-Transformed Human Retinal Pigment Epithelial Cells.- Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: maxiK, Cav1.3 and Bestrophin-1.- Lysosomal Trafficking Regulator (LYST).- Live-cell Imaging of Phagosome Motility in Primary Mouse RPE Cells.- RPE Cell and Sheet Properties in Normal and Diseased Eyes.- Valproic Acid Induced Human Retinal Pigment Epithelial Cell Death as Well as its Survival After Hydrogen Peroxide Damage is Mediated by P38 Kinase.- Blockade of MerTK Activation by AMPK Inhibits RPE Cell Phagocytosis.- Modulation of V-ATPase by ?A3/A1-crystallin in the Retinal Pigment Epithelial Cells.- Proteomic Profiling of Cigarette Smoke Induced Changes in Retinal Pigment Epithelium Cells.- Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress.