Mathematical Modeling of Protein Complexes

Mathematical Modeling of Protein Complexes

Kulikov, Kirill; Koshlan, Tatiana

Springer International Publishing AG

09/2018

367

Dura

Inglês

9783319983035

15 a 20 dias

740


ebook

Descrição não disponível.
Introduction.- Physical methods for studying proteins.- Physical properties of amino acids and proteins.- Selection of a biological objects.- Mathematical simulation of complex formation of protein molecules allowing for their domain structure.- Mathematical modeling of histone dimers formation in vitro with solutions of different ionic strength in the presence of monovalent salts.- Mathematical modeling of the temperature effect on binding of monomeric proteins in aqueous solutions by example on histones H2A, H2B, H3 and H4.- Mathematical modeling of the temperature effect on binding of different sites of protein BCL-XL in aqueous solutions.- Mathematical modeling of the phosphorylation effect on the nature formation of biological complexes P53-MDM2 and P53-P300.
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Protein Domain Binding;Effect of Phosphorylation on binding of proteins;Calculation of Reactivity of Proteins;Temperature Dependence Protein Complexes;Salt Dependence Protein Complexes;Amino Acids and Proteins;Histone Dimer Formation;Binding of Monomeric Proteins;Phosphorylation Effect;Simulation of Protein Complex Formation;Protein Structure