Disordered Vertebral and Rib Morphology in Pudgy Mice

I. INTRODUCTION.- II. MATERIALS AND METHODS.- 1. Source, distribution, and ages of pudgy and non-affected mice. - 2. Whole mount preparations.- 3. Radiographic studies.- 4. Histologic studies.- 5. Computerized three-dimensional reconstructions.- 6. Previous studies on chick vertebral development and human congenital scoliosis.- III. RESULTS.- 1. Gross appearance.- 2. Whole mount appearances.- 3. Radiographic studies.- 4. Histology studies: vertebrae, ribs, intervertebral discs and ganglia.- 5. Computerized three-dimensional reconstructions.- 6. Chick embryo vertebral development.- 7. Radiology and histopathology of human congenital scoliosis spine.- IV. DISCUSSION.- ion.- 3. The pudgy mouse.- 4. Genetic influences on axial development; mutations identified in mouse models with vertebral deformation.- 5. Congenital scoliosis (human); its similaritywith pudgy mouse vertebral abnormalities.- 6. Pathogenesis of pudgy and human congenital scoliosis based on histopathologic studies.-V. CONCLUSIONS.- 1. Implications of pudgy vertebral abnormalities for biologic research.- 2. Implications of pudgy vertebral abnormalities for clinical patient treatment.

Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.

• Biologia, ciências da vida
• Equipamentos científicos, experiências e técnicas
• Genética médica
• Zoologia e ciências animais

congenital scoliosis;human vertebral development;morphological gradients in deformity;spondylocostal dysplasia;rib malformation