Diabetic Nephropathy

Diabetic Nephropathy

Pathophysiology and Clinical Aspects

Vogt, Liffert; Roelofs, Joris J.

Springer International Publishing AG

11/2018

548

Dura

Inglês

9783319935201

15 a 20 dias

1260


ebook

Descrição não disponível.
1. Diabetic nephropathy - Scope of the problem.- Historical overview of diabetic kidney disease.- Clinical features and natural course of diabetic nephropathy.- Global, regional and ethnic differences in diabetic nephropathy.- Diabetic nephropathy in children and adolescents.- Renal disease in obesity, metabolic syndrome and diabesity.- 2. Pathophysiology and clinical pathology of the diabetic kidney.- Introduction to pathogenetic mechanisms of diabetic nephropathy.- The genetics of diabetic nephropathy.- Pathology of the kidney in diabetes.- 3. The glomerulus.- The mesangial cell in diabetic nephropathy.- The glomerular endothelium in diabetic nephropathy - role of heparanase.- The podocyte in diabetic nephropathy: recent advances.- Inflammatory processes in diabetic glomeruli.- 4. The tubulointerstitium.- Proteinuria and tubulotoxicity.- Tubulo-glomerular communication in diabetic nephropathy.- Mechanisms of interstitial fibrosis in diabetic nephropathy.- 5. Microvascular involvement.- Microvascular damage and hemodynamic alterations in diabetic nephropathy.- Coagulation and hemostasis in diabetic nephropathy.- Renal hemodynamics in diabetic kidney disease - relevance for intervention.- Microvascular complications in the eye: diabetic retinopathy.- 6. Macrovascular involvement.- Hypertension in diabetic kidney disease.- Macrovascular involvement in diabetes - renal artery stenosis.- Atherosclerosis and diabetic nephropathy.- 7. Experimental designs.- Animal models of diabetic kidney disease.- Clinical trial and error in diabetic nephropathy.- 8. Therapy of diabetic nephropathy.- Treatment goals in diabetic nephropathy.- Kidney transplantation and diabetic nephropathy.- 9. Future developments.- Health programs in low- and middle-income countries.- OMICs in diabetic kidney disease.- Future and novel compounds in the treatment of diabetic nephropathy.
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Chronic Kidney Disease;Type 2 Diabetes;Clinical Aspects;Basic Research;Research and Clinical Science;diabetes