Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment
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Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment
Garcia-Reyero, Natalia; Murphy, Cheryl
Springer International Publishing AG
03/2018
422
Dura
Inglês
9783319660820
15 a 20 dias
7745
Descrição não disponível.
1. Introduction.- Part I: Biology.- 2. "Non-model" species for eco and human health risk assessment.- 3.The fish embryo as a model for eco-toxicology and other potential models.- 4.Invertebrates/Plants.- 5.Behavioral/Neurobehavioral linkages to AOPs.- 6. Species extrapolation - common pathways etc.- 7. Life History Evolution, incorporating evolutionary processes into AOPs to extrapolate.- Part II: Incorporating Biology into AOPs.- 8.Use of HTS assays to infer MIEs.- 9. AOP development: how to infer and define KER.- 10. The development of quantitative AOPs.- Part IV: Incorporating Modeling into AOPs.-11.Computational approaches (network science, etc) in AOPs: linking molecular datasets.- 12.Computational approaches : Dynamic Energy Budgets.- 13. Modeling approaches in AOPs: extrapolation from individual to population.- 14. Modeling approaches that augment AOPs: GUTS, QSAR, TKTD PBTKTD.- 15. Exposure science and other stressors? How to incorporate.- 16. AOP as an organizing framework and implications for biological science-AOP evolution.- 17. Use and acceptance of AOPs for regulatory applications, use of AOPs in human risk assessment, and legislation.
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AOP;Ecotoxicological;Metabolomics;Molecular;Proteomics;Transcriptomics;Systems Biology
1. Introduction.- Part I: Biology.- 2. "Non-model" species for eco and human health risk assessment.- 3.The fish embryo as a model for eco-toxicology and other potential models.- 4.Invertebrates/Plants.- 5.Behavioral/Neurobehavioral linkages to AOPs.- 6. Species extrapolation - common pathways etc.- 7. Life History Evolution, incorporating evolutionary processes into AOPs to extrapolate.- Part II: Incorporating Biology into AOPs.- 8.Use of HTS assays to infer MIEs.- 9. AOP development: how to infer and define KER.- 10. The development of quantitative AOPs.- Part IV: Incorporating Modeling into AOPs.-11.Computational approaches (network science, etc) in AOPs: linking molecular datasets.- 12.Computational approaches : Dynamic Energy Budgets.- 13. Modeling approaches in AOPs: extrapolation from individual to population.- 14. Modeling approaches that augment AOPs: GUTS, QSAR, TKTD PBTKTD.- 15. Exposure science and other stressors? How to incorporate.- 16. AOP as an organizing framework and implications for biological science-AOP evolution.- 17. Use and acceptance of AOPs for regulatory applications, use of AOPs in human risk assessment, and legislation.
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
